Ashitaba - Articles, Books and Research

In this day and age when every day there seems to be some new "Miracle Cure," Lotion or Potion it is only to be expected that you would react with some level of skepticism.

With this in mind we have tried to compile articles, books, websites and research papers to help you further your reading and understanding of Ashitaba and its beneficial effects on your health.

Thank you for visiting our site.

We have organized the Articles and Research into categories.
It should be noted that much of the research on Ashitaba is performed in Japan and so articles and research papers that do not have an English translation or abstract have been omitted from this listing.

What is ASHITABA? - General Information on Ashitaba

ARTICLES and BOOKS

BOOK TITLE: Ashitaba, Nature's Longevity Herb by Dr. Howard Peiper, N.D.

BOOK TITLE : "Miracles by Ashitaba" by Dr. S. Yamanouchi PUBLISHER : Heart Publishing
ISBN :4-89295-037-8 C2077 P800E

BOOK TITLE : "Ashitaba, the Nutritional Treasure House" by Dr. S. Yamanouchi
PUBLISHER : Heart Publishing ISBN :4-8069-0262-4 C2047-P1000E

BOOK TITLE:"Marvelous Ashitaba" by Dr. H. Goto
PUBLISHER : Heart Publishing ISBN : 4-938564-52-1 C0277 P750E

Ashitaba, A Medicinal Plant and Health Method By Kazuo Hida pdf version

Research on the Effects of Ashitaba, Angelica Keiskei Koidzumi By Dr. Kevin Lance Jones, L.Ac., O.M.D.

Tooru Okuyama, Miraculous Ashitaba, Heart shuppan, 1994

Kimie Baba, Healthy vegetable Ashitaba, Chikuma shuubansha, 1995

Hida, Medicinal herb Ashitaba, Tsuchiya shyoten, 1991

Kazuo Izawa, Color Encyclopedia of Medicinal Herbs, Shufunotomo-sha, p501, 1998

TAKARA's scientists discover compounds enhancing in vivo production of Nerve Growth Factor

What is Ashitaba?

Ashitaba Fact Sheet from Planet Botanic

What is CHALCONE? - General Information on CHALCONES, Xanthoangelol, 4-hydroxyderricin, and Xanthoangelol E . (see also antioxidants, phytonutrients and flavonoids)

ARTICLES

Chalcones and Flavonoids

Xanthohumol Research

Xanthohumol, is a prenylated chalcone, found in hops. One would have to drink 120 gallons of beer per day to have any significant biological effect.

RESEARCH

The Interaction of Chalcones with Tubulin, N. J. Lawrence, A. T. McGown, S. Ducki and J. A. Hadfield, Anticancer Drug Design, 2000, 15, 135.

Potent antimitotic and cell growth inhibitory properties of substituted chalcones, S. Ducki, R. Forrest, J. A. Hadfield, A. Kendall, N. J. Lawrence, A. T. McGown and D. Rennison, Biorg. Med. Chem. Lett., 1998, 8, 1051.

Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro. J Agric Food Chem. 2000 Sep;48(9):3876-84.

Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells. Cancer Lett. 2000 Feb 28;149(1-2):21-9.

Inhibition of gastric H+, K(+)-ATPase by chalcone derivatives, xanthoangelol and 4-hydroxyderricin, from Angelica keiskei Koidzumi.Murakami S, Kijima H, Isobe Y, Muramatsu M, Aihara H, Otomo S, Baba K, Kozawa M.

Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus.Tabata N, Ito M, Tomoda H, Omura S.

Antitumor and antimetastatic activities of Angelica keiskei roots, part 1: Isolation of an active substance, xanthoangelol by Yoshiyuki Kimura, Kimiye Baba Publ in Cancer Diagnosis and Therapy

Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots.Kimura Y, Taniguchi M, Baba K. Planta Med. 2004 Mar;70(3):211-9. PMID: 15114497 [PubMed - indexed for MEDLINE]

Antibacterial, anti-ulcer, and anti-Hiv effects of chalcones (pdf file)

Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects. Akihisa T, Tokuda H, Hasegawa D, Ukiya M, Kimura Y, Enjo F, Suzuki T, Nishino H. J Nat Prod. 2006 Jan;69(1):38-42 - - inhibitory effects on the induction of Epstein-Barr virus, - - inhibitory effects on skin tumor promotion

Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects. Akihisa T, Tokuda H, Ukiya M, Iizuka M, Schneider S, Ogasawara K, Mukainaka T, Iwatsuki K, Suzuki T, Nishino H. Cancer Lett. 2003 Nov 25;201(2):133-7 - - antitumor-promoters

Four papers on Reduction of blood pressure and LDL cholesterol.

Artery Relaxation by Chalcones Isolated from the Roots of Angelica keiskei in Pharmacology Planta Med 2001; 67: 230-235

Anti-Tumor-Promotion by Principles Obtained from Angelica keiskei Okuyama, T.; Takata, M.; Takayasu, J.; Hasegawa, T.; Tokuda, H.; Nishino, A.; Nishino, H.; Iwashima, A. Full text as PDF (390 kb) Planta Medica; 03, 1991

Isobavachalcone, a Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma. Nishimura R, Tabata K, Arakawa M, Ito Y, Kimura Y, Akihisa T, Nagai H, Sakuma A, Kohno H, Suzuki T. Biol Pharm Bull. 2007 Oct;30(10):1878-83.

Xanthoangelol, a major chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma and leukemia cells. Tabata K, Motani K, Takayanagi N, Nishimura R, Asami S, Kimura Y, Ukiya M, Hasegawa D, Akihisa T, Suzuki T. Biol Pharm Bull. 2005 Aug;28(8):1404-7. PMID: 16079483 [PubMed - indexed for MEDLINE]

Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei.Enoki T, Ohnogi H, Nagamine K, Kudo Y, Sugiyama K, Tanabe M, Kobayashi E, Sagawa H, Kato I. J Agric Food Chem. 2007 Jul 25;55(15):6013-7. Epub 2007 Jun 21. PMID: 17583349 [PubMed - indexed for MEDLINE]

Beneficial effect of xanthoangelol, a chalcone compound from Angelica keiskei, on lipid metabolism in stroke-prone spontaneously hypertensive rats. Ogawa H, Okada Y, Kamisako T, Baba K. Clin Exp Pharmacol Physiol. 2007 Mar;34(3):238-43. PMID: 17250645 [PubMed - indexed for MEDLINE]

Beneficial effect of laserpitin, a coumarin compound from Angelica keiskei, on lipid metabolism in stroke-prone spontaneously hypertensive rats. [Clin Exp Pharmacol Physiol. 2005]

Xanthoangelol D isolated from the roots of Angelica keiskei inhibits endothelin-1 production through the suppression of nuclear factor-kappaB. Sugii M, Ohkita M, Taniguchi M, Baba K, Kawai Y, Tahara C, Takaoka M, Matsumura Y. Biol Pharm Bull. 2005 Apr;28(4):607-10. PMID: 15802795 [PubMed - indexed for MEDLINE]

The effects of xanthoangelol E on arachidonic acid metabolism in the gastric antral mucosa and platelet of the rabbit. Fujita T, Sakuma S, Sumiya T, Nishida H, Fujimoto Y, Baba K, Kozawa M. Res Commun Chem Pathol Pharmacol. 1992 Aug;77(2):227-40. PMID: 1439191 [PubMed - indexed for MEDLINE]

Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI. Inamori Y, Baba K, Tsujibo H, Taniguchi M, Nakata K, Kozawa M Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1604-5. PMID: 1934181 [PubMed - indexed for MEDLINE]

AN ANTI-FUNGAL PEPTIDE FROM ANGELICA KEISKEI Author; OBA TOSHIHARU(Takarabaio) NISHIMURA MARIKO(Takarabaio) ONOGI HIROMU(Takarabaio) ASADA KIYOZO(Takarabaio) KATO IKUNOSHIN(Takarabaio) Journal of the Pharmaceutical Society of Japan Journal Code:F0508A ISSN:0031-6903 VOL.126;NO.Suppl.3;PAGE.54-55(2006)

Why WHOLE FOODS and GREEN FOODS? - General Information on WHOLE FOODS and GREEN FOODS.

ARTICLES

Green Foods: A Research Perspective by David Sandoval Nutraceuticals World May 2003

RESEARCH

Ashitaba and the HEART. - General Information on Ashitaba and the HEART.

ARTICLES
RESEARCH

Effects of angiotensin I-converting enzyme inhibitor from Ashitaba (Angelica keiskei) on blood pressure of spontaneously hypertensive rats.Shimizu E, Hayashi A, Takahashi R, Aoyagi Y, Murakami T, Kimoto K.

Four papers on Reduction of blood pressure and LDL cholesterol.

Artery Relaxation by Chalcones Isolated from the Roots of Angelica keiskei in Pharmacology Planta Med 2001; 67: 230-235

Ashitaba and CANCER. - General Information on Ashitaba and CANCER.

ARTICLES

www.cancersalves.com/ article on Blood Purification

Anticancer Drug Design

Experiments suggest hop compounds fight cancer

RESEARCH

Linked Parallel Synthesis and MTT Bioassay Screening of Substituted Chalcones, N. J. Lawrence, D. Rennison, A. T. McGown, S. Ducki, L. A. Gul, J. A. Hadfield and N. Khan, J. Comb. Chem., 2001, 3, in press.

The Interaction of Chalcones with Tubulin, N. J. Lawrence, A. T. McGown, S. Ducki and J. A. Hadfield, Anticancer Drug Design, 2000, 15, 135.

Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells. Cancer Lett. 2000 Feb 28;149(1-2):21-9.

Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice. Cai Y, Kleiner H, Johnston D, Dubowski A, Bostic S, Ivie W, DiGiovanni J.

In vitro induction of the anticarcinogenic marker enzyme, quinone reductase, in human hepatoma cells by food extracts.Hashimoto K, Kawamata S, Usui N, Tanaka A, Uda Y.

Antitumor and antimetastatic activities of Angelica keiskei roots, part 1: Isolation of an active substance, xanthoangelol by Yoshiyuki Kimura, Kimiye Baba Publ in Cancer Diagnosis and Therapy

Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells. Kwon D, Yoon S, Carter O, Bailey GS, Dashwood RH. Biofactors. 2006;26(4):231-44. PMID: 17119270 [PubMed - indexed for MEDLINE]

Ashitaba and HIV/AIDS. - General Information on Ashitaba and HIV/AIDS.

ARTICLES

RESEARCH

Ashitaba and AIDS

"Dong Quai" or "Angelica sinensis".

Ashitaba and WOMEN'S health. - General Information on Ashitaba and WOMEN'S health.

ARTICLES

American Herbal Pharmacopoeia Publishes Dang Gui Root (Angelica sinensis) Monograph

Study Ties Hormone Therapy to Bolder, Stealthier Cancer by Thomas H.Maugh II Times staff writer 6/25/2003

Menopause? PMS?

RESEARCH

Relationship Between Long Durations and Different Regimens of Hormone Therapy and... Li et al. JAMA.2003; 289: 3254-3263.

Stimulating action of Carthamus tinctorius L., Angelica sinensis (Oliv.) Diels and Leonurus sibiricus L. on the uterus

Treating hot flushes without hormone replacement therapy. J Fam Pract. 2003 Apr;52(4):291-6. Review. No abstract available. PMID: 1268109

Use of alternative and complementary medicine in menopause. Int J Gynaecol Obstet. 2002 Dec;79(3):195-207. Review. PMID: 12445983Kang HJ, Ansbacher R, Hammoud MM.

Miscellaneous - Other articles and research concerning ashitaba

ARTICLES
RESEARCH

News 17 July, 2001 TAKARA's scientists discover compounds enhancing in vivo production of Nerve Growth Factor

NGF was first described by Rita Levi-Montalcini and collaborators as an important factor involved in nerve differentiation and survival. Another role for NGF has since been established in inflammation, in particular of the airways, with increased NGF levels in chronic inflammatory diseases. In this review, we will first describe NGF structure and synthesis and NGF receptors and their signalling pathways. We will then provide information about NGF in the airways, describing its expression and regulation, as well as pointing out its potential role in inflammation, hyperresponsiveness, and remodelling process observed in airway inflammatory diseases, in particular in asthma.

News 9 October, 2002 Takara Bio Inc. has discovered that components of the Angelica keiskei plant increase the production of a bone morphogenetic protein approximately tenfold in osteoblast Takara B

Role of neurotrophins in diabetic neuropathy and treatment with nerve growth factors. Tomlinson DR, Fernyhough P , Diemel LT, Department of Pharmacology, Medical Sciences, Queen Mary and Westfield College, London, United Kingdom.

Why PURIFY the BLOOD? - General Information on cleansing the blood

ARTICLES

http://www.naturalhealthnotebook.com/ on Blood Purification

www.cancersalves.com/ article on Blood Purification

RESEARCH

Why DETOXIFY? - General Information on detoxification

ARTICLES

Colon Cleansing by Shirley Trickett & Karen Brody

Irritable Bowel Syndrome & Diverticulosis (Thorsons, revised 1999)

Detoxification - An Ayurvedic Perspective

New Again! by Anna Selby (Ulysses Press, 1999) offers a 28-day detoxification plan

General Detoxification and Cleansing� Elson M. Haas M.D.

Detoxification -The Growing Problem Of Toxicity

Introduction to Internal Body Cleansing and Detoxification

RESEARCH

Food Fiber and Health

What are ANTIOXIDANTS?- General Information on antioxidants

ARTICLES

Anti-Oxidants for Disease Prevention by Chuck Balzer, MS RD

Antioxidant Flavonoids: Structure, Function and Clinical Usage By Alan L. Miller, ND

Antioxidant Activities of Flavonoids

Antioxidant Activity in Chinese Foods

The Antioxidants by Ron Kennedy, M.D., Santa Rosa, California

Learn how you could help your body with antioxidants !!

All About Antioxidants

Antioxidant Capacity and Health Benefits of Fruits and Vegetables

Antioxidants

Oxygen Radical Absorption Capacity (ORAC) Assay For Measuring Antioxidant Activity

Anti Aging Directory - Antioxidant Links

RESEARCH

What are FLAVONOIDS? - General Information on Flavonoids

ARTICLES

The Color of Health - Why Nutrients Called Flavonoids Are Good For You by Jack Challem, The Nutrition Reporter�

Chalcones and Flavonoids

Flavonoids in Tea

Antioxidant Flavonoids(listed in order of decreasing potency)

Antioxidant Activities of Flavonoids

USDA Database for the Flavonoid Content of Selected Foods

Finessing the Flavonoids

A Critical Look at the Flavonoids and Some Sound Recommendationsby Jack Challem

RESEARCH

"There is evidence that free-radical oxidation of LDL plays an important part in atherogenesis," Hertog and Feskins wrote in Lancet (Oct. 23,1993;342:1007-11). "Flavonoids are scavengers of free radicals...It is possible that quercetin and other flavonoids reduce the rate of formation of oxidised LDL and thus inhibit the growth of atherosclerotic plaques."

Influence of prenylated and non-prenylated flavonoids on liver microsomal lipid peroxidation and oxidative injury in rat hepatocytes ;Food Chem Toxicol. 2001 May;39(5):437-45.

Prenylflavonoids have anti-allergic, anti-inflammatory, anti-viral, anti-fungal, anti-bacterial, anti-oxidizing properties.
C.L.. Miranda et al: In Food and chemical Toxicology 37 (1999) 273 - 285; J.F. Stevens et al:In J Am. Soc. Brew. Chem. 56(4) 136 - 145, 1998 ; A Alt et al: Deutsches Krebsforschungszentrum. Abt. C0202, D-69129 Heidelberg.

What are Phytonutrients? - General Information on Phytonutrients

ARTICLES

Phytochemicals

Phenolic compound

Phytochemicals: Nutrients Of The Future By Marcia Zimmerman C.N.

RESEARCH

Green Tea- General Information on Green Tea

ARTICLES
RESEARCH

The benefits of tea flavonoids were confirmed earlier this year by researchers at the Saitama Cancer Research Center, Japan. K. Imai, PhD, and K. Nakachi, PhD, studied 1,371 men enrolled in a 40-year study of eating habits and health. They reported that elderly men who drank 10 or more cups of green tea daily had lower blood levels of cholesterol and triglycerides than men who drank less of the tea. "Consumption of green tea was significantly associated with lower serum concentrations of lipids and lipoproteins," they wrote in the British Medical Journal (March 18, 1995;310:693-6). "An increase in consumption substantially decreased serum total cholesterol and triglyceride concentrations, and this strong association remained almost unaltered even after age, cigarette smoking, alcohol consumption, and relative body weight were controlled for." The heavy tea drinkers also benefited from higher blood levels of the HDL and lower levels of the "bad" low-density lipoprotein (LDL) form of cholesterol. In addition, they had lower levels of certain liver enzymes, suggesting a reduced risk of liver disease. Drinking either green or black tea also protects against skin cancer by ultraviolet (UV) light and hazardous chemicals. In an experiment, Allan Conney, Ph.D., of the College of Pharmacy, Rutgers University, brewed four types of teas in concentrations comparable to what people drink: black tea, green tea, decaffeinated black tea, and decaffeinated green tea. He gave one type of each tea to four different groups of mice as their sole source of drinking fluid, then exposed them to either cancer-causing UV radiation or chemicals. For comparison's sake, he gave another group of mice plain water to drink. Conney reported in Cancer Research (July 1, 1994;54:3428-35) that the teas "markedly inhibited" the numbers and sizes of tumors.

Why ORGANIC? - General Information on organic food and farming.

ARTICLES

Organic Food Promotes Health & Ethical Choice

RESEARCH

Angelica - General Information on plants from the Angelica family including Angelica Sinensis (Dong Quai)

ARTICLES

angelica

RESEARCH

Stimulating action of Carthamus tinctorius L., Angelica sinensis (Oliv.) Diels and Leonurus sibiricus L. on the uterus

Treating hot flushes without hormone replacement therapy. J Fam Pract. 2003 Apr;52(4):291-6. Review. No abstract available. PMID: 1268109

Use of alternative and complementary medicine in menopause. Int J Gynaecol Obstet. 2002 Dec;79(3):195-207. Review. PMID: 12445983Kang HJ, Ansbacher R, Hammoud MM.

"Dong Quai" or "Angelica sinensis".

American Herbal Pharmacopoeia Publishes Dang Gui Root (Angelica sinensis) Monograph

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